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Acceptability of cell substrates for production of biologicals report of a WHO study group. by WHO Study Group on Biologicals.

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Published by World Health Organization ; Albany, NY : WHO Publications Centre USA [distributor] in Geneva .
Written in English

Subjects:

  • Biological products -- biosynthesis.,
  • Biological products.,
  • Cytology -- Research.

Book details:

Edition Notes

SeriesWorld Health Organization technical report series -- 747, Technical report series (World Health Organization) -- 747.
The Physical Object
Pagination29 p. :
Number of Pages29
ID Numbers
Open LibraryOL22386063M
ISBN 109241207477

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WHO Study Group on Biologicals. Acceptability of cell substrates for production of biologicals. Geneva: World Health Organization ; Albany, NY: WHO Publications Centre USA [distributor], (OCoLC) Material Type: Government publication, Internet resource: Document Type: Book, Internet Resource: All Authors / Contributors. The Second Annual W. Alton Jones Cell Science Center Symposium: Cell Substrates and­ Their Use in the Production of Vaccines and Other Biologicals was held October , The Center is an operational unit of the Tissue Culture Association and offers, in collaboration with the Association's Education Committee, a wide range of educational Author: John C. Petricciani. The Second Annual W. Alton Jones Cell Science Center Symposium: Cell Substrates and­ Their Use in the Production of Vaccines and Other Biologicals was held October , The Center is an operational unit of the Tissue Culture Association and offers, in collaboration with the Association's Education Committee, a wide range of educational. Cell Substrates for Biologics Production: Factors Affecting Acceptability. Authors; Authors and affiliations; John C. Petricciani it is of interest to examine which criteria are of major importance in assessing the acceptability of cells. The purpose of this discussion is to review those major criteria of acceptability which have been Cited by: 5.

At 1 day –1, perfusion cultures can be maintained for more than two months with cell viability above 70 %. Both in batch and perfusion mode the specific rate of antibody production is found independent of the cell growth rate between and day –1. KEY WORDS: Perfusion reactor, hollow-fiber, microfiltration, kinetics, OKT3, high density. 1. Background. The development of new biologicals is raising a number of challenges in evaluating novel cell substrates. In particular, the assessment of new cell lines derived from tumors or new animal cells that have not been used previously for the production of biological products for human use has been the subject of international expert reviews over the past by: This volume stems from a symposium sponsored by the W. Alton Jones Cell Science Center, Lake Placid New York. The Second Annual W. Alton Jones Cell Science Center Symposium: Cell Substrates and­ Their Use in the Production of Vaccines and Other Biologicals was held October , WHO requirements for the use of animal cells as in vitro substrates for the production of biologicals: application to influenza vaccine production. Griffiths E(1). Author information: (1)World Health Organization, Geneva, by: 7.

Animal cell substrates for the production of biologicals: An introduction to WHO documents Article (PDF Available) in Biologicals December with 37 Reads How we measure 'reads'. In response, WHO established a Study Group (SG) in that prepared an updated set of recommendations for using cell substrates for the production of biologicals. The early use of continuous cell lines (CCLs) for the manufacture of biological products is represented by the manufacture of foot-and-mouth disease vaccine in the Syrian hamster cell line baby hamster kidney (BHK), the production of interferon from the B-lymphoblastoid cell line Namalwa, and the introduction of monoclonal antibodies from hybridoma by: 8. Knezevic I, Stacey G, Petricciani J, Sheets R WHO Study Group on Cell Substrates. Evaluation of cell substrates for the production of biologicals: Revision of WHO recommendations. Report of the WHO Study Group on Cell Substrates for the Production of Biologicals, 22–23 April , Bethesda, MD. Biologicals – Cited by: 8.